Class IA PI3K regulatory subunits: p110-independent roles and structures
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چکیده
منابع مشابه
Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development
Mast cells are effector cells of the immune system that are derived from hematopoietic stem cells. These cells regulate both innate and adaptive immunity and have also been implicated in a variety of inflammatory diseases. The maturation of these cells is dependent on signals regulated via the c-Kit and IL-3 receptors as well as transcription factors including MITF. While the role of c-Kit and ...
متن کاملClass IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.
Class IA phosphoinositide 3-kinases (PI3Ks) signal downstream of tyrosine kinases and Ras and control a wide variety of biological responses. In mammals, these heterodimeric PI3Ks consist of a p110 catalytic subunit (p110alpha, p110beta, or p110delta) bound to any of five distinct regulatory subunits (p85alpha, p85beta, p55gamma, p55alpha, and p50alpha, collectively referred to as "p85s"). The ...
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The signaling lipid phosphatidylinositol 3,4,5, trisphosphate (PIP3) is an essential mediator of many vital cellular processes, including growth, survival, and metabolism. PIP3 is generated through the action of the class I phosphoinositide 3-kinases (PI3K), and their activity is tightly controlled through interactions with regulatory proteins and activating stimuli. The class IA PI3Ks are comp...
متن کاملRegulation of class IA PI3Ks: is there a role for monomeric PI3K subunits?
Class IA PI3Ks (phosphoinositide 3-kinases) consist of a p110 catalytic subunit bound to one of five regulatory subunits, known as p85s. Under unstimulated conditions, p85 stabilizes the labile p110 protein, while inhibiting its catalytic activity. Recruitment of the p85-p110 complex to receptors and adaptor proteins via the p85 SH2 (Src homology 2) domains alleviates this inhibition, leading t...
متن کاملDistinct roles of class IA PI3K isoforms in primary and immortalised macrophages.
The class IA isoforms of phosphoinositide 3-kinase (p110alpha, p110beta and p110delta) often have non-redundant functions in a given cell type. However, for reasons that are unclear, the role of a specific PI3K isoform can vary between cell types. Here, we compare the relative contributions of PI3K isoforms in primary and immortalised macrophages. In primary macrophages stimulated with the tyro...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2020
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20190845